1) An open wound, either a discharge of blood or other matter from the body or an incision designed to bleed a patient.

1647 This day I had much payne on my left arme by reason of the sorenesse of the issue, Thurlstone. The issue in this case was treatment for Adam Eyre who shortly before had purchased an issue plate, possibly a receptacle for the blood he was about to lose.

places Thurlstone
dates 1647

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